Anti-Plasmid Activity of Chlorpromazine in Types of Antibiotics Resistant Pathogenic Bacteria

This study was performed to evaluate the ability of chlorpromazine compound cure plasmids and remove antibiotic resistance character multidrug Gram-negative pathogenic bacteria. The curing experiment done by incubating bacterial strains in nutrient broth with sub MIC concentration chlorpromazine, disc diffusion method used before after pattern Synergetic test antibiotics that studied bacteria showed toward also done. results from four genera out five genera, where most plasmid removal cases E.cloacae, P.aeruginosa, P.merabilis, loss observed same but P.merabilis losing three nine were resistant them curing. As for synergistic effect, a synergism only two aforementioned genera. From this we concluded possibility removing eliminating through using antibiotics, will open way find new strategies treat many diseases caused